Brain gangliosides in the presenile dementia of Pick.
نویسندگان
چکیده
Histochemical analysis of frontal and temporal lobes from four patients with Pick presenile dementia indicated intracellular and extracellular deposits of gangliosides. Thin layer chromatography of gangliosides disclosed the presence of an unknown ganglioside, a decrease of N-acetylgalactosamine-GDla and an increase of GTla and/or GD2 in white matter of Pick brain. Chromatography of gray matter and quantitation of the sialic acid content yielded results similar to controls. It is suggested that degradation and removal of gangliosides is incomplete in Pick disease.
منابع مشابه
Diffuse neurofibrillary tangles with calcification: a new presenile dementia.
The term "diffuse neurofibrillary tangles with calcification" (DNTC) is proposed for a new form of presenile dementia. It is characterised by slowly progressive cortical dementia in the presenium, localised temporal or temporofrontal lobar atrophy, numerous neurofibrillary tangles widespread in the cerebral cortex, and pronounced calcareous deposits; 16 cases of DNTC, have been reported.
متن کاملA case of combined Pick's disease and Alzheimer's disease.
The diagnosis of combined Pick's and Alzheimer's disease is rare, and over the years different authors have used different criteria to arrive at such a diagnosis. A case is reported of presenile dementia in which the histological changes of Pick's disease and Alzheimer's disease were mingled. The brain showed no focal atrophy, but the Pick changes were most numerous in the hippocampus and in th...
متن کاملYOUNGER-ONSET DEMENTIA An introduction to younger-onset dementia syndromes
With advances in nutrition and medicine, longer life expectancies are accompanied by an increase in the number of people affected with dementia. Contrary to common perceptions, dementia is not a single disorder, but rather is an umbrella term used to refer to a number of different clinical presentations, each of which is associated with well-defined changes in the brain. While dementia is typic...
متن کاملCT Changes in Dementing Diseases : A Review 841
There are a number of diseases that can cause dementia. Some of these include presenile and senile illnesses of the Alzheimer's type, Pick's disease, CreutzfeldtJakob disease, multiple infarcts, dementia pugilistica, normal pressure hydrocephalus, and a variety of metabolic encephalopathies. While numerous studies have attempted to differentiate the CT scans of dementia patients from those of a...
متن کاملFatty acid composition of brain glycolipids in Alzheimer's disease, senile dementia, and cerebrocortical atrophy.
Quantitative fatty acid compositions are reported for human cerebral gray matter glycolipids (gangliosides, cerebrosides, and cerebroside sulfates) in Alzheimer's disease (presenile dementia) and related disorders of the central nervous system. Although the fatty acid compositions were generally similar to those of the controls, some significant differences were noted in Alzheimer's disease whi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of neurology, neurosurgery, and psychiatry
دوره 49 8 شماره
صفحات -
تاریخ انتشار 1986